• GK-No Needles icon No Needles
  • GK-No Gels icon No Gels
  • GK-Oral TRT icon Oral TRT
  • GK-Shipped to your door icon Shipped to your door
  • GK-shield-check icon No Insurance Needed
T Levels hero boardwalk image

KYZATREX®. FDA-Approved. Safe And Effective.

Oral Testosterone Replacement Therapy

Get Started For Only$99
Actor Portrayals

KYZATREX® (testosterone undecanoate) is a prescription oral testosterone treatment for adult men who have low or no testosterone levels due to certain medical conditions.

KYZATREX is a controlled substance (CIII) because it contains testosterone. It is not known if KYZATREX is safe or effective in males younger than 18 years old. Improper use may affect bone growth in children. It is not known if KYZATREX is safe or effective in men with “age-related hypogonadism” (also referred to as “late-onset hypogonadism”). KYZATREX is not meant for use by women.

Man checking his health results on his phone at the gym
Testosterone Levels 852ng/dL >450 100 - 450 < 100 Average Total Testosterone (ng/dL) Maximum total testosterone concentration Testosterone levels shown are illustrative only and not actual patient data or results. Actor Portrayal

Why Get KYZATREX® Helps

Get Your Testosterone Back Into Range

For men with clinically low testosterone, patients have reported improvements in sexual function, mood, and strength with testosterone therapy. Treatment is about more than changing a lab number—it addresses a diagnosed hormone deficiency that can affect how you feel and function.


KYZATREX® is an FDA-approved oral testosterone therapy designed to restore testosterone to a normal range in adult men with clinically low testosterone due to certain medical conditions.

Start Today For Only$99
Feel Like Something’s Off?
Low T May Be the Culprit
Nearly 4 in 10 men over the age of 45 have Low T levels.1  

If you experience any of the following symptoms, consider checking your testosterone levels.
Broken Heart 1Low Sex Drive
People Burnout 1Fatigue / Low Energy
Duration Jet Lag 1Difficulty Sleeping
Strenght 1Reduced Muscle Mass
Medical 2Decreased Bone Density
Body Scale with Weights 1Weight Gain
Bipolar Disorder 1Mood Changes
Focus 1Difficulty Concentrating
GET STARTED

Easy Hassle-Free Process

Start Testosterone Therapy in Days – Not Weeks

  1. Man completing an online health questionnaire on his phone Day 0

    Complete Your Intake

    Answer a few questions about your symptoms and health history online — takes minutes.

  2. Man collecting a blood sample at home using an at-home lab kit Day 2

    Get Your Labs at Home

    Lab work is required and included. Complete it at a walk-in location near you or with an at-home kit.

  3. Clinician reviewing lab results during a video consultation Day 4

    Provider Review

    A licensed clinician reviews your labs and intake to determine if KYZATREX is appropriate for you.

  4. Man opening a delivered package at home Day 6

    KYZATREX Delivered

    If prescribed, your medication ships directly to your door. Discreet packaging. Fast turnaround.

KYZATREX oral testosterone capsules *Not actual size Also available in 150 mg

Get Started for Only $99

Goes towards physician visit, labs, and medication

Start Today

This telehealth service is independent of Marius Pharmaceuticals and does not constitute a recommendation or referral for any specific product.

Effective Results with Oral TRT
KYZATREX is clinically proven to restore testosterone to normal levels.2 FDA-approved, liver-safe, and backed by an open-label, single-arm, multi-center trial in 139 hypogonadal men.2
chart-and-bottles
chart-bottles-mob
96percent
Up to 96% effective in clinical trials2*
Clinically proven to restore T to normal physiological range
2times
Increase in mean free testosterone2
More bioavailable testosterone where your body needs it
30percent
30% Decrease in mean SHBG levels3
SHBG can lock up testosterone, making it unavailable to your cells. Decreasing SHBG frees up more testosterone to do its job.4
*In a six-month clinical trial of 139 men with low testosterone, 88% of patients had normal testosterone levels at Day 90 (Cavg, 222-800 ng/dL) (worst case scenario calculation, excluding Investigator Site 104). Based on patients who completed the study (n=127), 96% of patients achieved normal testosterone levels at Day 90.
A couple talking and laughing together over dinner outdoors 2X Daily *Not actual size Also available in 150 mg

FDA-Approved Oral Testosterone

Not all TRT is Created Equal

Just two daily doses with food. See if KYZATREX fits into your life — no clinic visits for procedures, no mess, no pain.

Oral Capsule
No Mess
Painless
Injections
Pellets
Gels
Get Started

The Next Phase in Testosterone Treatment

How KYZATREX Works

KYZATREX® uses testosterone undecanoate, which is absorbed through the intestinal lymphatic system rather than undergoing first-pass metabolism in the liver.

Get Started
  • Layer_1

    Easy to Take

    Two daily doses, with food. No injections, no gels, no patches, just two doses twice a day.

  • Personalized treatment 1

    Flexible Dosing

    Multiple strengths allow your physician to personalize treatment.

  • Bypasses-The-Liver-Badge 1

    Bypasses the Liver

    Designed to avoid the liver toxicity associated with older oral testosterone treatments.2

Everything Included. Nothing Hidden.

Know Your Numbers

$99

  • Complete Hormone Panel
  • Available at Home or In Clinic
  • Physician Reviewed
  • Payment goes towards treatment if qualified
Get Started The Get KYZATREX app showing a testosterone lab result

TRT Treatment

$229 *Requires 3-month commitment /month

  • Oral capsule – no needles or gels
  • Simple twice-daily routine
  • Complete Hormone Panel included
  • KYZATREX medication
Get Started KYZATREX oral testosterone capsules *Not actual size Also available in 150 mg

Why Get KYZATREX

  • Online physician consultation
  • Get labs at home or in clinic
  • KYZATREX medication
  • No insurance needed
  • No long-term commitment

Have Questions?

Talk with a provider about your labs, medical history, and whether KYZATREX is right for you.

Let's Chat

Still Have Questions?

We've Got Answers.

Whether you're curious about cost, how the medication works, or what to expect, find what you need here.

What is KYZATREX?

KYZATREX is an FDA-approved oral testosterone for men who have low or no testosterone levels due to certain medical conditions.
KYZATREX is a controlled substance (CIII) because it contains testosterone. It is not known if KYZATREX is safe or effective in males younger than 18 years old. Improper use may affect bone growth in children. KYZATREX is not meant for use by women.
Learn more about KYZATREX.

Who can take KYZATREX?

KYZATREX is used to treat men who have low or no testosterone due to certain medical conditions. It is not known if KYZATREX is safe or effective in children younger than 18 years old. Improper use of KYZATREX may affect bone growth in children.
Do not take KYZATREX if you: have breast cancer; have or might have prostate cancer; are a woman who is pregnant (KYZATREX may harm your unborn baby); are allergic to KYZATREX or any of its ingredients.

How do I take KYZATREX?

KYZATREX is taken orally, with two doses a day alongside food. Your healthcare provider will provide specific instructions based on your treatment plan.

Is KYZATREX bad for my liver?

No. KYZATREX was specifically designed to be absorbed lymphatically. This means it bypasses your liver altogether, helping to avoid the liver toxicity often associated with previous generations of oral testosterone.1

How does KYZATREX work?
KYZATREX is an immediate-release oral testosterone undecanoate. It is absorbed through the lymphatic system, where the body then uses it to replace testosterone that has been lost as a result of various medical conditions.
How is low testosterone diagnosed?

Diagnosing Low T involves simple lab tests to measure your Total Testosterone (Total T) and Free Testosterone (Free T), along with Sex Hormone Binding Globulin (SHBG), which affects Free T availability. Total T gives an overall level, while Free T shows the testosterone available for your body’s use. High SHBG can lower Free T, impacting its availability. Your doctor may suggest these tests and follow-up labs to monitor your testosterone levels over time, ensuring your treatment is accurately tailored to your needs.

Is KYZATREX safe?

KYZATREX is a controlled substance (CIII) because it contains testosterone. It is not known if KYZATREX is safe or effective in males younger than 18 years old. Improper use may affect bone growth in children. KYZATREX is not meant for use by women.
In the phase 3 clinical trial for KYZATREX (n=155), 4 patients (2.6%) reported high blood pressure. A total of 5 patients (3.2%) began taking new antihypertensive medications after study start. No patient increased their dose of antihypertensive medication.
Your healthcare provider will monitor your blood pressure while you are being treated with KYZATREX. If your blood pressure increases, you may need to start medication to control your blood pressure. If you are currently taking blood pressure medicines, they may need to be changed or new blood pressure medicines may need to be added. If your blood pressure cannot be controlled, KYZATREX may need to be stopped.
See additional Important Safety Information for KYZATREX below.

References:
1. Mulligan, T et al. “Prevalence of hypogonadism in males aged at least 45 years: the HIM study.” International journal of clinical practice vol. 60,7 (2006): 762-9. doi:10.1111/j.1742-1241.2006.00992.x 
2. Bernstein JS, Dhingra OP. A phase III, single-arm, 6-month trial of a wide-dose range oral testosterone undecanoate product. Ther Adv Urol. 2024;16. doi:10.1177/17562872241241864 
3. Data on file. Raleigh, NC: Marius Pharmaceuticals, 2020.
4. Krakowsky Y, Grober E. Testosterone deficiency – Establishing a Biochemical Diagnosis. EJIFCC. 2015 Mar; 26(2): 105–113.PMID: 27683486; PMCID: PMC4975356.
What is KYZATREX®
KYZATREX® (testosterone undecanoate) is a prescription drug that is used to treat adult men who have low or no testosterone levels due to certain medical conditions.
KYZATREX® is a controlled substance (CIII) because it contains testosterone.
It is not known if KYZATREX® is safe or effective in males younger than 18 years old. Improper use may affect bone growth in children.
It is not known if KYZATREX® is safe or effective in men with “age-related hypogonadism” (also referred to as “late-onset hypogonadism”).
KYZATREX® is not meant for use by women.
Important Safety Information for KYZATREX®
Do not take KYZATREX® if you: have breast cancer; have or might have prostate cancer; are a woman who is pregnant (KYZATREX® may harm your unborn baby); or are allergic to KYZATREX® or any of its ingredients.
Before you take KYZATREX®, tell your healthcare provider about all of your medical conditions, including if you: have high blood pressure or are treated for high blood pressure; have a history of diabetes; have heart problems; have high red blood cell count (hematocrit) or high hemoglobin laboratory value; have urinary problems due to an enlarged prostate; have liver or kidney problems; or have problems breathing while you sleep (sleep apnea).
Tell your healthcare provider about all the medicines you take, including prescription and over-the-counter medicines, vitamins, and herbal supplements. Taking KYZATREX® with certain other medicines can affect each other. Especially, tell your healthcare provider if you take: insulin; medicines that decrease blood clotting (blood thinners); corticosteroids; or medicines that increase blood pressure, such as some cold medicine and pain medicines.
KYZATREX® may cause other serious side effects including:
  • Increase in red blood cell count (hematocrit) or hemoglobin, which can increase the risk of blood clots, strokes, and heart attacks. You may need to stop KYZATREX® if your red blood cell count increases.
  • If you already have an enlarged prostate, your signs and symptoms may worsen while taking KYZATREX®. These may include: increased urination at night; trouble starting your urine stream; urinating many times during the day; urge to go to the bathroom right away; a urine accident; inability to pass urine or weak urine flow.
  • Increased risk of prostate cancer.
  • Blood clots in the legs or lungs. Signs and symptoms of a blood clot in your leg can include pain, swelling or redness. Signs and symptoms of a blood clot in your lungs can include difficulty breathing or chest pain.
  • Abuse. Testosterone can be abused when taken at higher than prescribed doses and when used with other anabolic androgenic steroids. Abuse can cause serious heart and psychological side effects.
  • In large doses, KYZATREX® may lower your sperm count.
  • Liver problems. Symptoms of liver problems may include: nausea or vomiting; yellowing of your skin or whites of your eyes; dark urine; pain on the right side of your stomach area (abdominal pain).
  • Swelling of your ankles, feet, or body (edema), with or without heart failure.
  • Enlarged or painful breasts.
  • Breathing problems while you sleep (sleep apnea).
Call your healthcare provider right away if you have any of the serious side effects listed above.
The most common side effect of KYZATREX® is high blood pressure. Other side effects may include: headache, joint or back pain, diarrhea, increased red blood cell count, anxiety, constipation, swelling of the legs, and increased prostate specific antigen (PSA) levels.
These are not all the possible side effects of KYZATREX®. For more information, ask your healthcare provider or pharmacist.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch or call 1-800-FDA-1088. You may also report side effects to Marius by visiting www.mariuspharma.com.
Keep KYZATREX® and all medicines out of the reach of children.
See Full Prescribing Information and Medication Guide for KYZATREX® .